The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling.

pEF-BOS, a powerful mammalian expression vector

Seiichi Mizushima, Shigekazu Nagata · Nucleic Acids Research · 1990 · 1.6K citations · Full text

Protein Function, Signal Transduction, Protein Expression +6

Crystal structure of the tyrosine kinase domain of the human insulin receptor

Stevan R. Hubbard, Lei Wei, Wayne A. Hendrickson · Nature · 1994 · 1.1K citations

Crystal Structure, Insulin Signaling, Signal Transduction +12

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

David B. Straus · Cell · 1992 · 1K citations

Signal Transduction, Autoimmune Disease, Signaling Pathway +10

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Andrew C. Chan, Makio Iwashima, Christoph W. Turck et al. · Cell · 1992 · 1K citations

Protein Function, Signal Transduction, Molecular Physiology +12

Profound block in thymocyte development in mice lacking p56lck

Thierry Jo Molina, Kenji Kishihara, David P. Siderovski et al. · Nature · 1992 · 961 citations

Knockout Mouse, Signal Transduction, Cell Regulation +8