Hergen Spits

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

René de Waal Malefyt, John B.A.G. Haanen, Hergen Spits et al. · The Journal of Experimental Medicine · 1991 · 1.9K citations · Full text

Adaptive Immune System, T-regulatory Cell, Viral Immunity +20

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

Eric A. Reits, James W. Hodge, Carla Herberts et al. · The Journal of Experimental Medicine · 2006 · 1.7K citations · Full text

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

Jenny Mjösberg, Sara Trifari, Natasha K. Crellin et al. · Nature Immunology · 2011 · 1.1K citations · Full text

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

Jason S. McLellan, Man Chen, Michael Joyce et al. · Science · 2013 · 1.1K citations · Full text

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

Sara Trifari, Charles D. Kaplan, Elise H. Tran et al. · Nature Immunology · 2009 · 991 citations

Inflammation, Th2 Cells, Autoimmune Disease +10