Angewandte Chemie International Edition · 1998 · 22 citations · 0 references
PharmacyMedicinal ChemistryPharmacologyCombinatorial ChemistryDrug DesignDrug DiscoveryChemical Library DesignCombinatorial SynthesisEnzyme InhibitionLigand BindingLigand-based DesignMulti-target Drug DesignChemical Library SynthesisCombinatorial Library DesignEnzyme Inhibitor DiscoveryLead Compound DiscoveryMatrix MetalloproteinasesSmall-molecule Library DesignStructure-based Pharmacophore DesignTemplate-based Library Design
One common synthetic route creates small-molecule libraries directed toward two functionally distinct target families. The novel structural template 1 can independently display the necessary pharmacophore patterns for inhibition of members of two different biomolecular target families, the matrix metalloproteinases (MMPs) or the phosphodiesterases (PDEs). The incorporation of multiple target family directed design elements into combinatorial library design could help expedite the pharmaceutical lead discovery process. Z=OR' (PDE4), H (MMPs).