Concepedia

Combinatorial Library Design

Combinatorial Library Design is a methodological framework in enzyme evolution that systematically generates diverse molecular variants by strategically combining building blocks or genetic elements to construct multifunctional libraries for screening and selection purposes.

758

Publications

45.5K

Citations

3.2K

Authors

801

Institutions

Publications per year

2017–2026

91

Parents

Publications

758

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

Akin Akinc, Andreas Zumbuehl, Michael S. Goldberg et al. · Nature Biotechnology · 2008 · 1.2K citations

, , +16

De Novo Protein Design: Fully Automated Sequence Selection

Bassil I. Dahiyat, Stephen L. Mayo · Science · 1997 · 1.2K citations

, , +15

Encoded combinatorial chemistry.

Sydney Brenner, Richard A. Lerner · Proceedings of the National Academy of Sciences · 1992 · 1K citations

, , +17

Do Structurally Similar Molecules Have Similar Biological Activity?

Yvonne C. Martin, James L. Kofron, Linda Traphagen · Journal of Medicinal Chemistry · 2002 · 829 citations

, , +17

The Design of Leadlike Combinatorial Libraries

Simon J. Teague, A. M. Davis, Paul D. Leeson et al. · Angewandte Chemie International Edition · 1999 · 810 citations

, , +17

1–5 of 758

Authors

3.2K

  1. JK
    Jeremy K. M. Sanders

    University of Cambridge, United Kingdom

    19 publications · 1.9K citations

    19

    h-index

  2. SO
    Sijbren Otto

    University of Groningen, Netherlands

    11 publications · 875 citations

    11

    h-index

  3. KS
    Kit S. Lam

    University of California, Davis, United States

    10 publications · 196 citations

    10

    h-index

  4. MH
    Michael H. Hecht

    Princeton University, United States

    9 publications · 787 citations

    9

    h-index

  5. RA
    Richard A. Houghten

    Torrey Pines Institute For Molecular Studies, United States

    9 publications · 442 citations

    9

    h-index

1–5 of 3.2K

Institutions

801

  1. University of Cambridge

    Cambridge, United Kingdom

    22 h-index

    83 publications

    6.8K citations

  2. Scripps Research Institute

    San Diego, United States

    17 h-index

    66 publications

    10.4K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    16 h-index

    79 publications

    4K citations

  4. Torrey Pines Institute For Molecular Studies

    San Diego, United States

    13 h-index

    64 publications

    3.7K citations

  5. Princeton University

    Princeton, United States

    12 h-index

    46 publications

    3.9K citations

  6. University of California, Berkeley

    Berkeley, United States

    11 h-index

    36 publications

    2.4K citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    11 h-index

    40 publications

    15.4K citations

  8. University of Sheffield

    Sheffield, United Kingdom

    11 h-index

    30 publications

    4.3K citations

1–8 of 801

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 29 publications · 5.4K citations

    27

    h-index

  2. Journal of the American Chemical Society

    JACS · 31 publications · 3.5K citations

    27

    h-index

  3. Journal of Combinatorial Chemistry

    36 publications · 1.8K citations

    26

    h-index

  4. Angewandte Chemie International Edition

    28 publications · 2.7K citations

    25

    h-index

  5. Journal of Medicinal Chemistry

    24 publications · 2.4K citations

    22

    h-index

1–5