Richard A. Houghten

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

Richard A. Houghten · Proceedings of the National Academy of Sciences · 1985 · 1.7K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery

Richard A. Houghten, Clemencia Pinilla, Sylvie E. Blondelle et al. · Nature · 1991 · 1.3K citations

Pharmacy, Biotechnology, Medicinal Chemistry +16

The structure of an antigenic determinant in a protein

Ian A. Wilson, Henry Niman, Richard A. Houghten et al. · Cell · 1984 · 842 citations

Life Sciences, Biochemistry, Molecular Biology +11

Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence

James L. Bittle, Richard A. Houghten, Hannah Alexander et al. · Nature · 1982 · 817 citations

Life Sciences, Immunology, Infectious Diseases +13

Folding of immunogenic peptide fragments of proteins in water solution

H. Jane Dyson, Mark Rance, Richard A. Houghten et al. · Journal of Molecular Biology · 1988 · 735 citations

Life Sciences, Biochemistry, Immunology +14