A multifunctional catalyst that stereoselectively assembles prodrugs

Daniel A. DiRocco, Yining Ji, Edward C. Sherer, +11

Science

Supercritical fluid chromatography-photodiode array detection-electrospray ionization mass spectrometry as a framework for impurity fate mapping in the development and manufacture of drug substances

Gregory F. Pirrone, Rose Mathew, Alexey A. Makarov, +5

Journal of Chromatography B

Supercritical Fluid ChromatographyImpurity Fate MappingMedicineGas ChromatographyMass Spectrometry +8

Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of βII tryptase

Julian Levell, Peter C. Astles, Paul Eastwood, +32

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +6

Bridged .gamma.-carbolines and derivatives possessing selective and combined affinity for 5-HT2 and D2 receptors

Richard E. Mewshaw, Lisa S. Silverman, Rose Mathew, +6

Journal of Medicinal Chemistry

The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I

Christopher Hulme, K.J.M. Moriarty, Bruce E. Miller, +10

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryNovel SeriesBiochemistryNatural Sciences +8

Nanomolar Inhibitors for Two Distinct Biological Target Families from a Single Synthetic Sequence: A Next Step in Combinatorial Library Design?

Christopher J. Burns, Robert D. Groneberg, Joseph M. Salvino, +11

Angewandte Chemie International Edition

Synthesis of (D)- and (L)-forms of differentially protected 2-piperidinemethanamine

John Perumattam, Barry G. Shearer, William L. Confer, +1

Tetrahedron Letters

PharmacologyOrganic ChemistrySynthetic ChemistryChemistry

Orally active indole N-oxide PDE4 inhibitors

Christopher Hulme, Rose Mathew, K.J.M. Moriarty, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacological AgentPharmacotherapyPharmacology +3

Synthesis and in vitro evaluation of 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: high-affinity ligands for the N,N'-di-o-tolylguanidine-labeled .sigma. binding site

Richard E. Mewshaw, Ronald G. Sherrill, Rose Mathew, +3

Journal of Medicinal Chemistry

Drug TargetSigma SitesOrganic ChemistryChemical BiologyPharmaceutical Chemistry +15

Substituted 2-(aminomethyl)piperidines: a novel class of selective protein kinase C inhibitors

Barry G. Shearer, James P. Sullivan, J. Paul Carter, +5

Journal of Medicinal Chemistry

Drug TargetAltmetric Attention ScoreSystem PharmacologyHeterocycle ChemistryPharmaceutical Chemistry +18