Peter C. Astles

Total synthesis of furanocembranolides. 2. Macrocyclization studies culminating in the synthesis of a dihydropseudopterolide and gorgiacerone. Related furanocembranolide interconversions.

Christopher M. Rayner, Peter C. Astles, Leo A. Paquette · Journal of the American Chemical Society · 1992 · 76 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Total synthesis of furanocembranolides. 3. A concise convergent route to acerosolide

Leo A. Paquette, Peter C. Astles · The Journal of Organic Chemistry · 1993 · 70 citations

Natural Sciences, Chemistry, Pharmacology +7

Selective Cannabinoid Receptor Type 2 (CB2) Agonists: Optimization of a Series of Purines Leading to the Identification of a Clinical Candidate for the Treatment of Osteoarthritic Pain

Sean P. Hollinshead, Michael Tidwell, John R. Palmer et al. · Journal of Medicinal Chemistry · 2013 · 47 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Total Synthesis of (±)-α-Isosparteine, (±)-β-Isosparteine, and (±)-Sparteine from a Common Tetraoxobispidine Intermediate

Neil R. Norcross, J.P. Melbardis, M.F. Solera et al. · The Journal of Organic Chemistry · 2008 · 44 citations

Natural Sciences, Chemistry, Medicinal Chemistry +14

Species Selectivity of a Nicotinic Acetylcholine Receptor Agonist Is Conferred by Two Adjacent Extracellular β4 Amino Acids that Are Implicated in the Coupling of Binding to Channel Gating

Gareth T. Young, Lisa M. Broad, Ruud Zwart et al. · Molecular Pharmacology · 2006 · 41 citations

Medicine, Neuroscience, Pharmacology +17