Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al. · Nature · 1997 · 3.8K citations

Life Sciences, Genetics, Molecular Genetics +12

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

Hiroyuki Tamemoto, Takashi Kadowaki, Kazuyuki Tobe et al. · Nature · 1994 · 1.1K citations

Medicine, Biochemistry, Endocrinology +16

A Novel Locus, <i>Mody4</i>, Distal to D7Mit189 on Chromosome 7 Determines Early-Onset NIDDM in Nonobese C57BL/6 (Akita) Mutant Mice

Masato Yoshioka, Tsuyoshi Kayo, Tsurumi Ikeda et al. · Diabetes · 1997 · 523 citations

Medicine, Endocrinology, Genetics +12

New Perspectives on the Microvasculature of the Islets of Langerhans in the Rat

Susan Bonner‐Weir, Lelio Orci · Diabetes · 1982 · 482 citations

Medicine, Endocrinology, Physiology +12

Exercise induces recruitment of the “insulin-responsive glucose transporter”. Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle.

André G. Douen, Toolsie Ramlal, Sanjay Rastogi et al. · Journal of Biological Chemistry · 1990 · 476 citations · Full text

Life Sciences, Biochemistry, Physiology +17