Yoshio Ohyama

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al. · Nature · 1997 · 3.8K citations

Knockout Mouse, Mendelian Disorder, Aging +8

Klotho Protein Protects against Endothelial Dysfunction

Yuichiro Saito, Takahiro Yamagishi, Yoshio Ohyama et al. · Biochemical and Biophysical Research Communications · 1998 · 279 citations

Inflammation, Atherosclerosis, Physiology +8

In Vivo klotho Gene Delivery Protects against Endothelial Dysfunction in Multiple Risk Factor Syndrome

Yuichiro Saito, Tetsuya Nakamura, Yoshio Ohyama et al. · Biochemical and Biophysical Research Communications · 2000 · 259 citations

Inflammation, Endothelial Cell Pathobiology, Translational Medicine +12

Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging

Toshihiro Utsugi, Tomohisa Ohno, Yoshio Ohyama et al. · Metabolism · 2000 · 178 citations

Metabolic Syndrome, Insulin Production, Klotho Mutant Mouse +13

Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases

R Nagai, Yoshiaki Saito, Yoshio Ohyama et al. · Cellular and Molecular Life Sciences · 2000 · 167 citations · Full text

Inflammation, Metabolic Syndrome, Klotho Gene Expression +11