Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa, +13

Nature

Knockout MouseMendelian DisorderAgingGenetic DisorderGenetics +6

Identification of the HumanKlothoGene and Its Two Transcripts Encoding Membrane and SecretedKlothoProtein

Yutaka Matsumura, Hiroki Aizawa, Takako Shiraki-Iida, +3

Biochemical and Biophysical Research Communications

ChromatinSignal TransductionBiochemistryMedicineNatural Sciences +5

Structure of the mouse<i>klotho</i>gene and its two transcripts encoding membrane and secreted protein¹

Takako Shiraki-Iida, Hiroki Aizawa, Yutaka Matsumura, +6

FEBS Letters

Transcriptional RegulationSignal TransductionDevelopmental BiologyPromoter RegionNatural Sciences +13

Klotho Protein Protects against Endothelial Dysfunction

Yuichiro Saito, Takahiro Yamagishi, Yoshio Ohyama, +6

Biochemical and Biophysical Research Communications

InflammationAtherosclerosisPhysiologyImmunologyEndothelial Dysfunction +6

Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging

Toshihiro Utsugi, Tomohisa Ohno, Yoshio Ohyama, +13

Metabolism

Metabolic SyndromeInsulin ProductionKlotho Mutant MouseAgingLongevity +11

Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases

R Nagai, Yoshiaki Saito, Yoshio Ohyama, +5

Cellular and Molecular Life Sciences

InflammationMetabolic SyndromeKlotho Gene ExpressionMedicineVascular Adaptation +9

Disruption of the <i>klotho</i> Gene Causes Pulmonary Emphysema in Mice

Tatsuo Suga, Masahiko Kurabayashi, Yoshichika Sando, +9

American Journal of Respiratory Cell and Molecular Biology

Coffee and Green Tea As a Large Source of Antioxidant Polyphenols in the Japanese Population

Yoichi Fukushima, Takashi Ohie, Yasuhiko Yonekawa, +8

Journal of Agricultural and Food Chemistry

NutritionDietary ExposureTotal Polyphenol ConsumptionPolyphenolicsOxidative Stress +14

Molecular Cloning of RatklothocDNA: Markedly Decreased Expression ofklothoby Acute Inflammatory Stress

Yoshio Ohyama, Masahiko Kurabayashi, Hiroaki Masuda, +10

Biochemical and Biophysical Research Communications

InflammationAcute Inflammatory StressAnti-inflammatoryAutoimmune DiseaseLung Inflammation +9

Downregulation of theKlothoGene in the Kidney under Sustained Circulatory Stress in Rats

Hiroki Aizawa, Yuichiro Saito, Tetsuya Nakamura, +13

Biochemical and Biophysical Research Communications

UrologyRenal FunctionMedicinePhysiologyVascular Biology +8