Hiroki Aizawa

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al. · Nature · 1997 · 3.8K citations

Knockout Mouse, Mendelian Disorder, Aging +8

Identification of the HumanKlothoGene and Its Two Transcripts Encoding Membrane and SecretedKlothoProtein

Yutaka Matsumura, Hiroki Aizawa, Takako Shiraki-Iida et al. · Biochemical and Biophysical Research Communications · 1998 · 680 citations

Chromatin, Signal Transduction, Biochemistry +7

Structure of the mouse<i>klotho</i>gene and its two transcripts encoding membrane and secreted protein¹

Takako Shiraki-Iida, Hiroki Aizawa, Yutaka Matsumura et al. · FEBS Letters · 1998 · 303 citations

Transcriptional Regulation, Signal Transduction, Developmental Biology +15

Klotho Protein Protects against Endothelial Dysfunction

Yuichiro Saito, Takahiro Yamagishi, Yoshio Ohyama et al. · Biochemical and Biophysical Research Communications · 1998 · 279 citations

Inflammation, Atherosclerosis, Physiology +8

Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging

Toshihiro Utsugi, Tomohisa Ohno, Yoshio Ohyama et al. · Metabolism · 2000 · 178 citations

Metabolic Syndrome, Insulin Production, Klotho Mutant Mouse +13