Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa, +13

Nature

Knockout MouseMendelian DisorderAgingGenetic DisorderGenetics +6

CD40 Ligation Releases Immature Dendritic Cells from the Control of Regulatory CD4+CD25+ T Cells

Pau Serra, Abdelaziz Amrani, Jun Yamanouchi, +5

Immunity

Autoimmune DiseaseT-regulatory CellImmunologyAutoimmunityCd4 T Cell Responses +6

Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging

Toshihiro Utsugi, Tomohisa Ohno, Yoshio Ohyama, +13

Metabolism

Metabolic SyndromeInsulin ProductionKlotho Mutant MouseAgingLongevity +11

Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic <i>beta</i> -cells in nonobese diabetic mice.

Michio Nagata, Pere Santamaría, Toshihiko Kawamura, +2

The Journal of Immunology

Acceleration of spontaneous diabetes in TCR-beta-transgenic nonobese diabetic mice by beta-cell cytotoxic CD8+ T cells expressing identical endogenous TCR-alpha chains

Joan Verdaguer, Ji‐Won Yoon, Brad Anderson, +4

The Journal of Immunology

Large-Scale Sidereal Anisotropy of Galactic Cosmic-Ray Intensity Observed by the Tibet Air Shower Array

M. Amenomori, S. Ayabe, S. W. Cui, +76

The Astrophysical Journal

Doctor-Patient Communication: A Comparison betweenTelemedicine Consultation and Face-to-Face Consultation

Xiao Liu, Yoshie Sawada, Takako Takizawa, +8

Internal Medicine

Perforin-independent β-cell destruction by diabetogenic CD8+ T lymphocytes in transgenic nonobese diabetic mice

Abdelaziz Amrani, Joan Verdaguer, Brad Anderson, +3

Journal of Clinical Investigation

Hypoxia Induces Transcription of the Plasminogen Activator Inhibitor-1 Gene Through Genistein-Sensitive Tyrosine Kinase Pathways in Vascular Endothelial Cells

Tsuyoshi Uchiyama, Masahiko Kurabayashi, Yoshio Ohyama, +6

Arteriosclerosis Thrombosis and Vascular Biology

Hypoxia Induces TranscriptionCellular PhysiologyVascular Endothelial CellsOxidative StressThrombosis +15

A New Type of CD4+ Suppressor T cell Completely Prevents Spontaneous Autoimmune Diabetes and Recurrent Diabetes in Syngeneic Islet-Transplanted NOD Mice

Hye-Seung Han, Hee‐Sook Jun, Toshihiro Utsugi, +1

Journal of Autoimmunity

Recurrent DiabetesIslet TransplantationAutoimmune DiseaseNew TypeT-regulatory Cell +9