Toshihiro Utsugi

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al. · Nature · 1997 · 3.8K citations

Knockout Mouse, Mendelian Disorder, Aging +8

CD40 Ligation Releases Immature Dendritic Cells from the Control of Regulatory CD4+CD25+ T Cells

Pau Serra, Abdelaziz Amrani, Jun Yamanouchi et al. · Immunity · 2003 · 286 citations · Full text

Autoimmune Disease, T-regulatory Cell, Immunology +8

Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging

Toshihiro Utsugi, Tomohisa Ohno, Yoshio Ohyama et al. · Metabolism · 2000 · 178 citations

Metabolic Syndrome, Insulin Production, Klotho Mutant Mouse +13

Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic <i>beta</i> -cells in nonobese diabetic mice.

Michio Nagata, Pere Santamaría, Toshihiko Kawamura et al. · The Journal of Immunology · 1994 · 160 citations

Acceleration of spontaneous diabetes in TCR-beta-transgenic nonobese diabetic mice by beta-cell cytotoxic CD8+ T cells expressing identical endogenous TCR-alpha chains

Joan Verdaguer, Ji‐Won Yoon, Brad Anderson et al. · The Journal of Immunology · 1996 · 129 citations