Klotho Signaling is a molecular regulatory pathway in which the Klotho protein acts as a co-receptor or circulating hormone to modulate phosphate and vitamin D metabolism, thereby influencing mineral bone homeostasis in the context of chronic kidney disease.
650
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2017–2026
325
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Publications
650
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
PubMed · 1997 · 66.6K citations
FGF23 induces left ventricular hypertrophy
Christian Faul, Ansel P. Amaral, Behzad N. Oskouei et al. · Journal of Clinical Investigation · 2011 · 2K citations
Suppression of Aging in Mice by the Hormone Klotho
Hiroshi Kurosu, Masaya Yamamoto, Jeremy D. Clark et al. · Science · 2005 · 1.9K citations · Full text
Education, Endocrinology, Genetics +17
Klotho converts canonical FGF receptor into a specific receptor for FGF23
Itaru Urakawa, Yuji Yamazaki, Takashi Shimada et al. · Nature · 2006 · 1.8K citations
Regulation of Fibroblast Growth Factor-23 Signaling by Klotho
Hiroshi Kurosu, Yasushi Ogawa, Masayoshi Miyoshi et al. · Journal of Biological Chemistry · 2006 · 1.4K citations · Full text
1–5 of 650
Authors
4.2K
- MKMakoto Kuro‐o
The University of Texas Southwestern Medical Center, United States
62 publications · 15.4K citations
45
h-index
- ZSZhongjie Sun
University of Oklahoma Health Sciences Center, United States
15 publications · 1.4K citations
15
h-index
- OWOrson W. Moe
The University of Texas Southwestern Medical Center, United States
15 publications · 5.7K citations
15
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- BL
14
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- MM
14
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1K
The University of Texas Southwestern Medical Center
Dallas, United States
49 h-index
215 publications
85.8K citations
Harvard University
Cambridge, United States
27 h-index
115 publications
10.3K citations
University of Oklahoma Health Sciences Center
Oklahoma City, United States
15 h-index
37 publications
3.5K citations
New York University
New York, United States
15 h-index
45 publications
12.7K citations
Jichi Medical University
Shimotsuke, Japan
14 h-index
16 publications
1.1K citations
Southern Medical University
Guangzhou, China
14 h-index
98 publications
8K citations
Kyoto University
Kyoto, Japan
13 h-index
38 publications
4.2K citations
University of Tübingen
Tübingen, Germany
13 h-index
87 publications
3.6K citations
1–8 of 1K
Venues
- Kidney International
24 publications · 3.4K citations
24
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- PLoS ONE
23 publications · 1.7K citations
22
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- Biochemical and Biophysical Research Communications
BBRC · 18 publications · 1.4K citations
17
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- Scientific Reports
18 publications · 755 citations
14
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- Nephrology Dialysis Transplantation
NDT · 13 publications · 1K citations
13
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