PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

Naoto Kubota, Yasuo Terauchi, Hiroshi Miki, +25

Molecular Cell

Insulin ResistanceObesityMetabolic SyndromeBiochemistryDiabetes +8

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

Hiroyuki Tamemoto, Takashi Kadowaki, Kazuyuki Tobe, +15

Nature

Insulin ResistanceMetabolic SyndromeInsulin SignalingGrowth HormoneInsulin Receptor Substrate-1 +9

Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.

Akira Okuno, Hiroyuki Tamemoto, Kazuuki TOBE, +9

Journal of Clinical Investigation

Metabolic DisorderMetabolic RemodelingInsulin SignalingObesityMetabolic Syndrome +20

Parthenogenetic activation of oocytes in c-mos-deficient mice

Naohiro Hashimoto, Nobumoto Watanabe, Yasuhide Furuta, +8

Nature

OocyteKnockout MouseDevelopmental BiologyCell DivisionOogenesis +6

Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes

Tsutomu Yamazaki, Kazuyuki Tobe, Eitetsu Hoh, +7

Journal of Biological Chemistry

Cardiac MuscleEngineeringCytoskeletonMechanotransductionMechanical Loading +20

Insulin Signalling and Insulin Actions in the Muscles and Livers of Insulin-Resistant, Insulin Receptor Substrate 1-Deficient Mice

Toshimasa Yamauchi, Kazuyuki Tobe, Hiroyuki Tamemoto, +10

Molecular and Cellular Biology

Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

Toshimasa Yamauchi, Kohjiro Ueki, Kazuyuki Tobe, +13

Nature

Signal TransductionMolecular PhysiologyGrowth HormoneHuman GrowthReceptor Tyrosine Kinase +8

A Novel Negative Selection for Homologous Recombinants Using Diphtheria Toxin A Fragment Gene

Takeshi Yagi, Shigeyuki Nada, Nobumoto Watanabe, +4

Analytical Biochemistry

EngineeringReverse GeneticsGeneticsDirected EvolutionNovel Negative Selection +10

Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.

Hideki Abe, N Yamada, Katsuo Kamata, +10

Journal of Clinical Investigation

HypertensionHyperlipidemiaGlucose ToleranceInsulin SignalingEndothelium-dependent Vascular Relaxation +19

Increased Levels of Interleukin 33 in Sera and Synovial Fluid from Patients with Active Rheumatoid Arthritis

Yasushi Matsuyama, Hitoaki Okazaki, Hiroyuki Tamemoto, +9

The Journal of Rheumatology