SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

Philip D. Jeffrey, Alicia A. Russo, Kornélia Polyák et al. · Nature · 1995 · 1.4K citations

Signal Transduction, Signaling Pathway, Molecular Pathway +10

Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors

Moosa Mohammadi, Gerald McMahon, Li Sun et al. · Science · 1997 · 1.1K citations · Full text

Molecular Biology, Cell Growth, Signaling Pathway +17

Crystal structure of cyclin-dependent kinase 2

Hendrik L. De Bondt, Jody Rosenblatt, Jarmila Jancarik et al. · Nature · 1993 · 965 citations

Crystal Structure, Biochemistry, Natural Sciences +5

Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors

Nathanael S. Gray, Lisa Wodicka, A.M.W.H. Thunnissen et al. · Science · 1998 · 806 citations · Full text

Synthesis and Biological Evaluations of 3-Substituted Indolin-2-ones:  A Novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particular Receptor Tyrosine Kinases

Li Sun, Ngoc Quang Tran, Flora Tang et al. · Journal of Medicinal Chemistry · 1998 · 486 citations · Full text

Medicinal Chemistry, Pharmaceutical Chemistry, Biochemistry +14