Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

Philip D. Jeffrey, Alicia A. Russo, Kornélia Polyák, +4

Nature

Signal TransductionSignaling PathwayMolecular PathwayCyclina-cdk2 ComplexNatural Sciences +8

Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors

Moosa Mohammadi, Gerald McMahon, Li Sun, +5

Science

Molecular BiologyCell GrowthSignaling PathwayReceptor Tyrosine KinaseFibroblast Growth Factor +15

Crystal structure of cyclin-dependent kinase 2

Hendrik L. De Bondt, Jody Rosenblatt, Jarmila Jancarik, +3

Nature

Crystal StructureBiochemistryNatural SciencesProtein X-ray CrystallographyMolecular Biology +3

Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors

Nathanael S. Gray, Lisa Wodicka, A.M.W.H. Thunnissen, +10

Science

Synthesis and Biological Evaluations of 3-Substituted Indolin-2-ones:  A Novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particular Receptor Tyrosine Kinases

Li Sun, Ngoc Quang Tran, Flora Tang, +4

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryBiochemistryRtk ActivityMedicine +12

Cyclin-Dependent Kinase Inhibitors:  Useful Targets in Cell Cycle Regulation

Thais M. Sielecki, John F. Boylan, Pamela A. Benfield, +1

Journal of Medicinal Chemistry

Drug TargetAltmetric Attention ScoreCell CyclePre-clinical PharmacologySystems Pharmacology +18

Design, Synthesis, and Evaluations of Substituted 3-[(3- or 4-Carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as Inhibitors of VEGF, FGF, and PDGF Receptor Tyrosine Kinases

Li Sun, Ngoc Quang Tran, Congxin Liang, +7

Journal of Medicinal Chemistry

Tyrosine KinaseImmunologyPharmacotherapyPharmaceutical ChemistryMedicinal Chemistry +14

Oxindole-Based Inhibitors of Cyclin-Dependent Kinase 2 (CDK2):  Design, Synthesis, Enzymatic Activities, and X-ray Crystallographic Analysis

H. Neal Bramson, J. Corona, Stephen T. Davis, +18

Journal of Medicinal Chemistry

Oxindole-based InhibitorsOxindole-based CompoundsLigand DockingCell CycleHeterocycle Chemistry +14

Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent.

Dirk B. Mendel, Alexander Laird, Beverly D. Smolich, +8

PubMed

Anti-angiogenesis AgentReceptor TyrosineAngiogenesisMedicineReceptor Tyrosine Kinase +12

Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

Stephen T. Davis, Bill Benson, H. Neal Bramson, +23

Science

Cdk InhibitorsChemoprevention StrategyHair LossMedicinePharmacology +9