Estimation of Drug-Metabolizing Capacity by Cytochrome P450 Genotyping and Expression

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

F. Peter Guengerich, M V Martin, Philippe Beaune et al. · Journal of Biological Chemistry · 1986 · 730 citations · Full text

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

Marguerite A. Butler, M. Iwasaki, F. Peter Guengerich et al. · Proceedings of the National Academy of Sciences · 1989 · 638 citations · Full text

Metabolomic Profiling, Pharmacotherapy, Cytochrome P-450pa +16

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

Thomas Kronbach, Daniel Mathys, Makoto Umeno et al. · Molecular Pharmacology · 1989 · 534 citations

Preparation and Properties of Partially Purified Cytochrome P-450 and Reduced Nicotinamide Adenine Dinucleotide Phosphate-Cytochrome P-450 Reductase from Rabbit Liver Microsomes

Theodore A. van der Hoeven, Minor J. Coon · Journal of Biological Chemistry · 1974 · 519 citations · Full text

Rabbit Liver Microsomes, Fatty Liver Disease, Fatty Acids +16

Evaluation of Cytochrome P450 Probe Substrates Commonly Used by the Pharmaceutical Industry to Study in Vitro Drug Interactions

Rae Yuan, Soraya Madani, Xiaoxiong Wei et al. · Drug Metabolism and Disposition · 2002 · 323 citations