Concepedia

Cyp2d6 Genotype

CYP2D6 Genotype is a genetic profile that specifies the allelic variants of the CYP2D6 gene, which encodes a key cytochrome P450 enzyme involved in the metabolism of numerous pharmacological agents, particularly relevant in pediatric pharmacogenomics for predicting drug response and dosage requirements.

1.5K

Publications

84.5K

Citations

7.1K

Authors

2K

Institutions

Publications per year

2017–2026

272

Parents

Publications

1.5K

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.

Christoph Sachse, Jürgen Brockmöller, Steffen Bauer et al. · PubMed · 1997 · 979 citations

, , +17

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for <i>CYP2D6</i> and <i>CYP2C19</i> Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors

J K Hicks, JR Bishop, Katrin Sangkuhl et al. · Clinical Pharmacology & Therapeutics · 2015 · 975 citations · Full text

, , +17

CYP2D6 Genotype, Antidepressant Use, and Tamoxifen Metabolism During Adjuvant Breast Cancer Treatment

Zeruesenay Desta, Vered Stearns, Brent B. Ward et al. · JNCI Journal of the National Cancer Institute · 2005 · 942 citations · Full text

, , +17

Active Tamoxifen Metabolite Plasma Concentrations After Coadministration of Tamoxifen and the Selective Serotonin Reuptake Inhibitor Paroxetine

Vered Stearns · JNCI Journal of the National Cancer Institute · 2003 · 849 citations · Full text

, , +17

The CYP2D6 Activity Score: Translating Genotype Information into a Qualitative Measure of Phenotype

Andrea Gaedigk, S.D. Simon, R PEARCE et al. · Clinical Pharmacology & Therapeutics · 2007 · 793 citations

, , +16

1–5 of 1.5K

Authors

7.1K

  1. AG
    Andrea Gaedigk

    Children's Mercy Hospital, United States

    56 publications · 9.4K citations

    37

    h-index

  2. AL
    Adrián LLerena

    Universidad de Extremadura, Spain

    39 publications · 2.4K citations

    25

    h-index

  3. MD
    Marja­‐Liisa Dahl

    Karolinska Institutet, Sweden

    25 publications · 2.4K citations

    22

    h-index

  4. LB
    Leif Bertilsson

    Karolinska Institutet, Sweden

    25 publications · 2.8K citations

    21

    h-index

  5. MI
    Magnus Ingelman‐Sundberg

    Karolinska Institutet, Sweden

    22 publications · 3K citations

    21

    h-index

1–5 of 7.1K

Institutions

2K

  1. Karolinska Institutet

    Stockholm, Sweden

    44 h-index

    255 publications

    20.9K citations

  2. Children's Mercy Hospital

    Kansas City, United States

    31 h-index

    105 publications

    19.1K citations

  3. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology

    Stuttgart, Germany

    28 h-index

    176 publications

    19.2K citations

  4. Universidad de Extremadura

    Badajoz, Spain

    27 h-index

    158 publications

    7.7K citations

  5. Indiana University – Purdue University Indianapolis

    Indianapolis, United States

    26 h-index

    130 publications

    16.8K citations

  6. Karolinska University Hospital

    Stockholm, Sweden

    25 h-index

    90 publications

    4.6K citations

  7. University of Toronto

    Toronto, Canada

    22 h-index

    73 publications

    6.1K citations

  8. Mayo Clinic

    Rochester, United States

    20 h-index

    112 publications

    18K citations

1–8 of 2K

Venues

  1. Clinical Pharmacology & Therapeutics

    CPT · 92 publications · 13.6K citations

    60

    h-index

  2. European Journal of Clinical Pharmacology

    77 publications · 4K citations

    40

    h-index

  3. Pharmacogenetics

    64 publications · 4.3K citations

    40

    h-index

  4. British Journal of Clinical Pharmacology

    BJCP · 50 publications · 2.9K citations

    30

    h-index

  5. PubMed

    Repository · 75 publications · 4.4K citations

    29

    h-index

1–5