Leif Bertilsson

A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants

Sung Eun Sim, Carl Risinger, Eleni Aklillu et al. · Clinical Pharmacology & Therapeutics · 2006 · 729 citations

Medicine, Pharmacokinetics, Pharmacology +17

"Serotonin Depression"—A Biochemical Subgroup Within the Affective Disorders?

Marie Åsberg, Peter Thorén, Lil Träskman et al. · Science · 1976 · 679 citations

Medicine, Pharmacology, Psychiatry +17

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

Ida Johansson, E Lundqvist, Leif Bertilsson et al. · Proceedings of the National Academy of Sciences · 1993 · 647 citations

Medicine, Genetics, Molecular Genetics +17

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

Inger Johansson, Mikael Oscarson, Qun‐Ying Yue et al. · Molecular Pharmacology · 1994 · 430 citations

Medicine, Genetics, Molecular Genetics +16

Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.

Eleni Aklillu, Irene Persson, Leif Bertilsson et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 396 citations

Life Sciences, Genetics, Pharmacology +17