Concepedia

Challenges in the development of mGluR5 positive allosteric modulators: The discovery of CPPHA

Zhijian Zhao, David D. Wisnoski, Julie A. O’Brien, Wei Lemaire, David L. Williams, Marlene A. Jacobson, Marion Wittman, Sookhee Ha, Hervé Schaffhauser, Cyrille Sur,

Bioorganic & Medicinal Chemistry Letters · 2006 · 71 citations · 11 references

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11

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Craig W. Lindsley, Zhijian Zhao, William Leister et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 501 citations · Full text

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A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models

Gene G. Kinney, Julie A. O’Brien, Wei Lemaire et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 299 citations

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Polymer-Supported Quenching Reagents for Parallel Purification

Robert J. Booth, John C. Hodges · Journal of the American Chemical Society · 1997 · 265 citations

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A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5

Julie A. O’Brien, Wei Lemaire, Tsing‐Bau Chen et al. · Molecular Pharmacology · 2003 · 209 citations

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A Novel Selective Allosteric Modulator Potentiates the Activity of Native Metabotropic Glutamate Receptor Subtype 5 in Rat Forebrain

Julie A. O’Brien, Wei Lemaire, Marion Wittmann et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 172 citations

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