Modeling Human Cytochrome P450 2D6 Metabolism and Drug-Drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines

Manipulating the mouse embryo: A laboratory manual

Martin Johnson · Trends in Genetics · 1986 · 2.3K citations

Veterinary Medicine, Cell Biology, Developmental Biology +12

A new logic for DNA engineering using recombination in Escherichia coli

Youming Zhang, Frank Buchholz, Joep P. P. Muyrers et al. · Nature Genetics · 1998 · 1.2K citations

Life Sciences, Biotechnology, Molecular Biology +16

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.

Christoph Sachse, Jürgen Brockmöller, Steffen Bauer et al. · PubMed · 1997 · 979 citations

Medicine, Genetics, Pharmacology +17

THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”

Mary F. Paine, Heather L. Hart, Shana S. Ludington et al. · Drug Metabolism and Disposition · 2006 · 874 citations

Medicine, Biochemistry, Pharmacology +12

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

Frank J. Gonzalez, Radek C. Skodat, Shioko Kimura et al. · Nature · 1988 · 718 citations

Life Sciences, Genetics, Molecular Genetics +12