C. Roland Wolf

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

Michael McMahon, Ken Itoh, Masayuki Yamamoto et al. · PubMed · 2001 · 656 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver

M.D. Burke, S. Thompson, Richard Weaver et al. · Biochemical Pharmacology · 1994 · 555 citations

Medicine, Biochemistry, Pharmacology +14

Feedback control of AHR signalling regulates intestinal immunity

Chris Schiering, Emma Wincent, Amina Metidji et al. · Nature · 2017 · 542 citations · Full text

Life Sciences, Immunology, Molecular Biology +14

Mutations in APC, Kirsten-ras, and p53—alternative genetic pathways to colorectal cancer

Gillian Smith, Francis A. Carey, Julie Beattie et al. · Proceedings of the National Academy of Sciences · 2002 · 522 citations

Medicine, Genetics, Oncology +17

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

Simon A. Chanas, Qingwu Jiang, Michael McMahon et al. · Biochemical Journal · 2002 · 448 citations · Full text

Pharmacy, Genetics, Toxicology +17