Simon A. Chanas

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

Michael McMahon, Ken Itoh, Masayuki Yamamoto et al. · PubMed · 2001 · 656 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

Simon A. Chanas, Qingwu Jiang, Michael McMahon et al. · Biochemical Journal · 2002 · 448 citations · Full text

Pharmacy, Genetics, Toxicology +17

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

John D. Hayes, Simon A. Chanas, Colin J. Henderson et al. · Biochemical Society Transactions · 2000 · 318 citations

Life Sciences, Biochemistry, Pharmacology +17

Corneal Development, Limbal Stem Cell Function, and Corneal Epithelial Cell Migration in the<i>Pax6</i>^+/−Mouse

J. Martin Collinson, Simon A. Chanas, Robert E. Hill et al. · Investigative Ophthalmology & Visual Science · 2004 · 156 citations

Medicine, Developmental Biology, Genetics +17

Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver.

Vincent P. Kelly, Elizabeth M. Ellis, Margaret M. Manson et al. · PubMed · 2000 · 146 citations · Full text

Pharmacy, Pharmacology, Toxicology +16