John D. Hayes

p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

Ashish Jain, Trond Lamark, Eva Sjøttem et al. · Journal of Biological Chemistry · 2010 · 1.5K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression

Michael McMahon, Ken Itoh, Masayuki Yamamoto et al. · Journal of Biological Chemistry · 2003 · 1.1K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12

SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

Patricia Rada, Ana I. Rojo, Sudhir Chowdhry et al. · Molecular and Cellular Biology · 2011 · 744 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

Michael McMahon, Ken Itoh, Masayuki Yamamoto et al. · PubMed · 2001 · 656 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

Sudhir Chowdhry, Yiguo Zhang, Michael McMahon et al. · Oncogene · 2012 · 635 citations · Full text

Life Sciences, Molecular Biology, Oncology +15