Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse Line

Maki Hasegawa, Yury Kapelyukh, Harunobu Tahara, +6

Molecular Pharmacology

Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice

Yury Kapelyukh, Colin J. Henderson, Nico Scheer, +2

Drug Metabolism and Disposition

Modeling Human Cytochrome P450 2D6 Metabolism and Drug-Drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines

Nico Scheer, Yury Kapelyukh, Jillian McEwan, +4

Molecular Pharmacology

Multiple Substrate Binding by Cytochrome P450 3A4: Estimation of the Number of Bound Substrate Molecules

Yury Kapelyukh, Mark J. I. Paine, Jean‐Didier Maréchal, +3

Drug Metabolism and Disposition

Generation and Characterization of Novel Cytochrome P450 Cyp2c Gene Cluster Knockout and CYP2C9 Humanized Mouse Lines

Nico Scheer, Yury Kapelyukh, Lynsey R. Chatham, +3

Molecular Pharmacology

In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice

Nico Scheer, Jillian Ross, Yury Kapelyukh, +2

Drug Metabolism and Disposition

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

Colin J. Henderson, Yury Kapelyukh, Nico Scheer, +7

Drug Metabolism and Disposition

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model

Nico Scheer, Yury Kapelyukh, Anja Rode, +6

Drug Metabolism and Disposition

A Role for Cytochrome b5 in the In Vivo Disposition of Anticancer and Cytochrome P450 Probe Drugs in Mice

Colin J. Henderson, Lesley A. McLaughlin, ROBERT FINN, +3

Drug Metabolism and Disposition

Quantifying ERK activity in response to inhibition of the BRAFV600E-MEK-ERK cascade using mathematical modelling

Sara Hamis, Yury Kapelyukh, Aileen McLaren, +3

British Journal of Cancer