Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse Line

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

Peter Kuehl, Jiong Zhang, Yvonne Lin et al. · Nature Genetics · 2001 · 2.2K citations

Life Sciences, Genetics, Molecular Biology +17

Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands

Linda B. Moore, Derek J. Parks, Stacey A. Jones et al. · Journal of Biological Chemistry · 2000 · 810 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Humanized xenobiotic response in mice expressing nuclear receptor SXR

Wen Xie, Joyce L. Barwick, Michael Downes et al. · Nature · 2000 · 657 citations

Life Sciences, Molecular Biology, Toxicology +12

Comparative Metabolic Capabilities of CYP3A4, CYP3A5, and CYP3A7

J. Andrew Williams, Barbara J. Ring, Varon E. Cantrell et al. · Drug Metabolism and Disposition · 2002 · 468 citations

Medicine, Biochemistry, Pharmacology +17

Developmental Expression of the Major Human Hepatic CYP3A Enzymes

Jeffrey Stevens, Ronald N. Hines, Chungang Gu et al. · Journal of Pharmacology and Experimental Therapeutics · 2003 · 364 citations

Life Sciences, Biochemistry, Developmental Biology +16