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A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys

Animal PhysiologySclerostinBone ResorptionMedicinePhysiologyBone RemodelingOsteoarthritisCathepsin KElevated Bone TurnoverBone HomeostasisPharmacologyOsteoporosisBone MetabolismOsteocalcinHealth Sciences