Concepedia

Cathepsin Dysfunction

Cathepsin Dysfunction is a pathological condition characterized by impaired activity or regulation of lysosomal cathepsin proteases, leading to disrupted protein degradation and cellular homeostasis within the broader context of lysosomal dysfunction.

854

Publications

50.5K

Citations

5.3K

Authors

1.4K

Institutions

Publications per year

2017–2026

165

Parents

Publications

854

Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency

Bruce D. Gelb, Guo‐Ping Shi, Harold A. Chapman et al. · Science · 1996 · 1K citations

, , +17

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

Paul Säftig, Ernst B. Hunziker, Olaf Wehmeyer et al. · Proceedings of the National Academy of Sciences · 1998 · 910 citations

, , +17

A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy

Denise Hilfiker‐Kleiner, Karol Kamiński, Edith Podewski et al. · Cell · 2007 · 897 citations · Full text

, , +12

Distinct roles for cysteine cathepsin genes in multistage tumorigenesis

Vasilena Gocheva, Wei Zeng, Danxia Ke et al. · Genes & Development · 2006 · 579 citations · Full text

, , +17

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

Tanaya Shree, Oakley C. Olson, Benelita T. Elie et al. · Genes & Development · 2011 · 532 citations · Full text

, , +17

1–5 of 854

Authors

5.3K

  1. TR
    Thomas Reinheckel

    University of Freiburg, Germany

    21 publications · 2.5K citations

    20

    h-index

  2. PS
    Paul Säftig

    Christian-Albrechts-Universität zu Kiel, Germany

    22 publications · 3.7K citations

    20

    h-index

  3. CP
    Christoph Peters

    University of Freiburg, Germany

    20 publications · 3.1K citations

    19

    h-index

  4. GS
    Guo‐Ping Shi

    Brigham and Women's Hospital, United States

    17 publications · 2.2K citations

    16

    h-index

  5. JK
    Janko Kos

    Jožef Stefan Institute, Slovenia

    13 publications · 723 citations

    13

    h-index

1–5 of 5.3K

Institutions

1.4K

  1. Harvard University

    Cambridge, United States

    24 h-index

    69 publications

    7.3K citations

  2. Inserm

    Paris, France

    24 h-index

    175 publications

    8.4K citations

  3. University of Freiburg

    Freiburg im Breisgau, Germany

    19 h-index

    81 publications

    11.3K citations

  4. Brigham and Women's Hospital

    Boston, United States

    18 h-index

    66 publications

    6.6K citations

  5. Christian-Albrechts-Universität zu Kiel

    Kiel, Germany

    17 h-index

    24 publications

    1.6K citations

  6. Jožef Stefan Institute

    Ljubljana, Slovenia

    16 h-index

    34 publications

    2K citations

  7. Juntendo University

    Tokyo, Japan

    13 h-index

    77 publications

    11.6K citations

  8. Soochow University

    Suzhou, China

    12 h-index

    90 publications

    3.9K citations

1–8 of 1.4K

Venues

  1. PubMed

    Repository · 28 publications · 1.8K citations

    18

    h-index

  2. Biochemical and Biophysical Research Communications

    BBRC · 18 publications · 738 citations

    14

    h-index

  3. Bone

    14 publications · 1K citations

    13

    h-index

  4. PLoS ONE

    12 publications · 446 citations

    12

    h-index

  5. Oncogene

    11 publications · 1.4K citations

    11

    h-index

1–5