Concepedia

Cdk5 Is a Key Factor in Tau Aggregation and Tangle Formation In Vivo

Wendy Noble, Vicki Olm, Kazuyuki Takata, Evelyn Casey, O Mary, Jordana L. Meyerson, Kate Gaynor, John J. LaFrancois, Lili Wang, Takayuki Kondo,

Neuron · 2003 · 507 citations · 48 references

DOIFull text

Open access

Concepts

References

48

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

Inge Grundke‐Iqbal, Khalid Iqbal, M Quinlan et al. · Journal of Biological Chemistry · 1986 · 1.8K citations · Full text

, , +14

Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP

Jada Lewis, Dennis W. Dickson, Wen-Lang Lin et al. · Science · 2001 · 1.6K citations

, , +15

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

Gentry N. Patrick, Lawrence Zukerberg, Margareta Nikolić et al. · Nature · 1999 · 1.5K citations

, , +10

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

Jürgen Götz, F. Chen, Jo Van Dorpe et al. · Science · 2001 · 1.5K citations

, , +14

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

Jada Lewis, Eileen McGowan, Julia M. Rockwood et al. · Nature Genetics · 2000 · 1.4K citations

, , +16