Concepedia

Tau Aggregation

Tau Aggregation is a pathological process wherein the microtubule-associated protein tau undergoes conformational misfolding and self-assembly into insoluble neurofibrillary fibrils, a hallmark mechanism in neurodegenerative tauopathies.

1.8K

Publications

167.3K

Citations

9.4K

Authors

1.8K

Institutions

Publications per year

2017–2026

960

Parents

Publications

1.8K

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

Michel Goedert, Maria Grazia Spillantini, Ross Jakes et al. · Neuron · 1989 · 2.5K citations

, , +16

Cryo-EM structures of tau filaments from Alzheimer’s disease

Anthony W. P. Fitzpatrick, Benjamin Falcon, Shaoda He et al. · Nature · 2017 · 2.1K citations

, , +16

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

Maria Grazia Spillantini, Jill R. Murrell, Michel Goedert et al. · Proceedings of the National Academy of Sciences · 1998 · 1.5K citations

, , +17

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

Jada Lewis, Eileen McGowan, Julia M. Rockwood et al. · Nature Genetics · 2000 · 1.4K citations

, , +16

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

Bess Frost, Rachel Lauren Jacks, Marc I. Diamond · Journal of Biological Chemistry · 2009 · 1.3K citations · Full text

, , +17

1–5 of 1.8K

Authors

9.4K

  1. EM
    Eckhard Mandelkow�

    Max Planck Unit for Structural Molecular Biology, Germany

    82 publications · 19K citations

    56

    h-index

  2. MG
    Michel Goedert

    MRC Laboratory of Molecular Biology, United Kingdom

    54 publications · 18.9K citations

    41

    h-index

  3. JQ
    John Q. Trojanowski

    University of Pennsylvania, United States

    41 publications · 7.2K citations

    35

    h-index

  4. VM
    Virginia M.‐Y. Lee

    University of Pennsylvania, United States

    41 publications · 7.9K citations

    35

    h-index

  5. JB
    Jacek Biernat

    Max Planck Unit for Structural Molecular Biology, Germany

    36 publications · 8.8K citations

    34

    h-index

1–5 of 9.4K

Institutions

1.8K

  1. University of Pennsylvania

    Philadelphia, United States

    50 h-index

    344 publications

    53.4K citations

  2. Max Planck Unit for Structural Molecular Biology

    Hamburg, Germany

    49 h-index

    238 publications

    65.5K citations

  3. German Center for Neurodegenerative Diseases

    Bonn, Germany

    46 h-index

    320 publications

    33K citations

  4. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    46 h-index

    262 publications

    94.1K citations

  5. Inserm

    Paris, France

    39 h-index

    294 publications

    24.6K citations

  6. Harvard University

    Cambridge, United States

    37 h-index

    274 publications

    53.5K citations

  7. Université de Lille

    Lille, France

    36 h-index

    212 publications

    19K citations

  8. University of Cambridge

    Cambridge, United Kingdom

    36 h-index

    251 publications

    21.9K citations

1–8 of 1.8K

Venues

  1. Journal of Biological Chemistry

    JBC · 105 publications · 15.2K citations

    68

    h-index

  2. Biochemistry

    62 publications · 7K citations

    47

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 44 publications · 12.2K citations

    40

    h-index

  4. Journal of Alzheimer s Disease

    JAD · 74 publications · 4.9K citations

    38

    h-index

  5. Acta Neuropathologica

    42 publications · 4.6K citations

    35

    h-index

1–5