Concepedia

Tau Synaptic Dysfunction

Tau Synaptic Dysfunction is a pathological construct describing the impairment of synaptic structure and function resulting from aberrant tau protein localization, aggregation, or post-translational modification in pre- and post-synaptic compartments, distinct from synaptic dysfunction arising from other neurodegenerative mechanisms.

188

Publications

18K

Citations

1.4K

Authors

383

Institutions

Publications per year

2017–2026

96

Parents

Publications

188

Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Yasumasa Yoshiyama, Makoto Higuchi, Bin Zhang et al. · Neuron · 2007 · 2.3K citations · Full text

, , +16

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

Cristian A. Lasagna‐Reeves, Diana L. Castillo‐Carranza, Urmi Sengupta et al. · Molecular Neurodegeneration · 2011 · 618 citations · Full text

, , +17

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

Borislav Dejanovic, Melanie A. Huntley, Ann De Mazière et al. · Neuron · 2018 · 551 citations · Full text

, , +16

Cdk5 Is a Key Factor in Tau Aggregation and Tangle Formation In Vivo

Wendy Noble, Vicki Olm, Kazuyuki Takata et al. · Neuron · 2003 · 507 citations · Full text

, , +14

Alzheimer's disease: Aβ, tau and synaptic dysfunction

Frank M. LaFerla, Salvatore Oddo · Trends in Molecular Medicine · 2005 · 463 citations

, , +12

1–5 of 188

Authors

1.4K

  1. TL
    Tara L. Spires‐Jones

    University of Edinburgh, United Kingdom

    8 publications · 1.7K citations

    9

    h-index

  2. KD
    Karen Duff

    Nathan Kline Institute for Psychiatric Research, United States

    6 publications · 1.2K citations

    6

    h-index

  3. BT
    Bradley T. Hyman

    Massachusetts General Hospital, United States

    6 publications · 1.2K citations

    6

    h-index

  4. JL
    Jada Lewis

    Mayo Clinic in Florida, United States

    6 publications · 522 citations

    6

    h-index

  5. DW
    Dennis W. Dickson

    Mayo Clinic in Florida, United States

    6 publications · 1K citations

    6

    h-index

1–5 of 1.4K

Institutions

383

  1. German Center for Neurodegenerative Diseases

    Bonn, Germany

    10 h-index

    40 publications

    2.6K citations

  2. UK Dementia Research Institute

    London, United Kingdom

    9 h-index

    48 publications

    3.9K citations

  3. Massachusetts General Hospital

    Boston, United States

    8 h-index

    37 publications

    8.8K citations

  4. Inserm

    Paris, France

    8 h-index

    45 publications

    4.7K citations

  5. University College London

    London, United Kingdom

    8 h-index

    21 publications

    1.1K citations

  6. Mayo Clinic in Florida

    Jacksonville, United States

    8 h-index

    51 publications

    9.3K citations

  7. Harvard University

    Cambridge, United States

    8 h-index

    38 publications

    8.9K citations

  8. University of Cambridge

    Cambridge, United Kingdom

    7 h-index

    65 publications

    3.6K citations

1–8 of 383

Venues

  1. Neurobiology of Aging

    16 publications · 1.2K citations

    14

    h-index

  2. Acta Neuropathologica

    12 publications · 1K citations

    12

    h-index

  3. Neuron

    8 publications · 4.4K citations

    8

    h-index

  4. Neurobiology of Disease

    8 publications · 733 citations

    8

    h-index

  5. Journal of Alzheimer s Disease

    JAD · 7 publications · 551 citations

    7

    h-index

1–5