Concepedia

Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

Sanne Weijzen, Paola Rizzo, Mike Braid, Radhika Vaishnav, Suzanne Jonkheer, Andrei Zlobin, Barbara A. Osborne, Sridevi Gottipati, Jon C. Aster, William C. Hahn,

Nature Medicine · 2002 · 547 citations · 41 references

DOI

Concepts

References

41

ras oncogenes in human cancer: a review.

Joyce Bos · PubMed · 1989 · 5.1K citations

, , +17

Creation of human tumour cells with defined genetic elements

William C. Hahn, Christopher M. Counter, Ante S. Lundberg et al. · Nature · 1999 · 2.3K citations

, , +13

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

Bart De Strooper, Wim Annaert, Philippe Cupers et al. · Nature · 1999 · 2.1K citations

, , +12

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

Leif W. Ellisen, Daniel C. West, A. Lee Soreng et al. · Cell · 1991 · 1.7K citations

, , +14

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Eric H. Schroeter, Jeffrey A. Kisslinger, Raphael Kopan · Nature · 1998 · 1.6K citations

, , +13