Concepedia

PD-L1 partially protects renal tubular epithelial cells from the attack of CD8+cytotoxic T cells

Ying Waeckerle‐Men, Astrid Starke, R. Wüthrich

Nephrology Dialysis Transplantation · 2007 · 62 citations · 36 references

Open access

Abstract

Together our data reveal that the renal PD-L1/PD-1 pathway has a negative effect on CD8+ CTL activation. PD-L1 might, therefore, act as a protective molecule on TEC, downregulating the cytotoxic renal parenchymal immune response.

References

36

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

Haidong Dong, Scott E. Strome, Diva R. Salomão et al. · Nature Medicine · 2002 · 4.9K citations

Immune Evasion, Cancer Immunosurveillance, T-cell Apoptosis +7

Restoring function in exhausted CD8 T cells during chronic viral infection

Daniel L. Barber, E. John Wherry, David Masopust et al. · Nature · 2005 · 3.9K citations

T-regulatory Cell, Immunology, Virology +8

T cell receptor antagonist peptides induce positive selection

Kristin A. Hogquist, Stephen C. Jameson, William R. Heath et al. · Cell · 1994 · 2.8K citations

T-regulatory Cell, Immunology, Positive Selection +7

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

Hiroyuki Nishimura, Masato Nose, Hiroshi Hiai et al. · Immunity · 1999 · 2.7K citations · Full text

Immunogenetics, Allergy, Autoimmune Disease +11

Tissue expression of PD-L1 mediates peripheral T cell tolerance

Mary Keir, Spencer C. Liang, Indira Guleria et al. · The Journal of Experimental Medicine · 2006 · 1.2K citations · Full text

T-regulatory Cell, Immunology, Immune Regulation +16