Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

Spencer C. Liang, Xiangyang Tan, Deborah Luxenberg, +4

The Journal of Experimental Medicine

Microbial PathogensImmunologyImmune RegulationEnhance ExpressionAntimicrobial Peptides +16

Tissue expression of PD-L1 mediates peripheral T cell tolerance

Mary Keir, Spencer C. Liang, Indira Guleria, +7

The Journal of Experimental Medicine

T-regulatory CellImmunologyImmune RegulationImmunologic MechanismImmunotherapy +14

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

Yvette Latchman, Spencer C. Liang, Yin Wu, +6

Proceedings of the National Academy of Sciences

Adaptive Immune SystemT-regulatory CellImmunologyImmune RegulationImmunodominance +22

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

Spencer C. Liang, Yvette Latchman, Janet E. Buhlmann, +4

European Journal of Immunology

IL-22 is required for Th17 cell–mediated pathology in a mouse model of psoriasis-like skin inflammation

Hak‐Ling Ma, Spencer C. Liang, Jing Li, +10

Journal of Clinical Investigation

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8⁺ T cell activation and cytolysis

Nancy Rodig, Timothy A. Ryan, Jessica A. Allen, +8

European Journal of Immunology

An IL-17F/A Heterodimer Protein Is Produced by Mouse Th17 Cells and Induces Airway Neutrophil Recruitment

Spencer C. Liang, Andrew Long, Frann Bennett, +8

The Journal of Immunology

InflammationCytokineInflammatory Lung DiseaseAutoimmune DiseaseLung Inflammation +13

IL-21 Has a Pathogenic Role in a Lupus-Prone Mouse Model and Its Blockade with IL-21R.Fc Reduces Disease Progression

Deborah Herber, Thomas Brown, Spencer C. Liang, +3

The Journal of Immunology

IL-22 Induces an Acute-Phase Response

Spencer C. Liang, Cheryl Nickerson‐Nutter, Debra D. Pittman, +10

The Journal of Immunology

InflammationIl-22 ActivityPhysiological ParametersCytokineIl-22 Protein +13

PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function

Sarah Whelan, Eran Ophir, Maya F. Kotturi, +17

Cancer Immunology Research