Concepedia

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

Brian T. Fife, Kristen E. Pauken, Todd N. Eagar, Takashi Obu, Jenny Wu, Qizhi Tang, Miyuki Azuma, Matthew F. Krummel, Jeffrey A. Bluestone

Nature Immunology · 2009 · 743 citations · 42 references

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42

Restoring function in exhausted CD8 T cells during chronic viral infection

Daniel L. Barber, E. John Wherry, David Masopust et al. · Nature · 2005 · 4K citations

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

Elizabeth Tivol, Frank Borriello, Alain Schweitzer et al. · Immunity · 1995 · 2.9K citations · Full text

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CTLA-4 can function as a negative regulator of T cell activation

Theresa L. Walunas, Deborah J. Lenschow, Christina Y. Bakker et al. · Immunity · 1994 · 2.2K citations

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CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

Richard V. Parry, Jens M. Chemnitz, Kenneth A. Frauwirth et al. · Molecular and Cellular Biology · 2005 · 1.9K citations · Full text

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Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

Manish J. Butte, Mary Keir, Theresa B. Phamduy et al. · Immunity · 2007 · 1.7K citations · Full text

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