Concepedia

Tolerance Mechanisms

Tolerance Mechanisms is a biological process within the adaptive immunity system that establishes immunological non-reactivity to self-antigens and harmless foreign antigens through central and peripheral mechanisms, thereby preventing autoimmunity while maintaining immune responsiveness to pathogens.

3K

Publications

216.8K

Citations

10.3K

Authors

1.9K

Institutions

Publications per year

2017–2026

227

Variants

Immunological Tolerance Mechanisms

Parents

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Publications

3K

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Shimon Sakaguchi, N Sakaguchi, M Asano et al. · The Journal of Immunology · 1995 · 5.5K citations

, , +17

‘Actively Acquired Tolerance’ of Foreign Cells

R. E. Billingham, L Brent, P. B. Medawar · Nature · 1953 · 3.1K citations

, , +14

T cell tolerance by clonal elimination in the thymus

John W. Kappler, Neal W. Roehm, Philippa Marrack · Cell · 1987 · 2.2K citations

, , +14

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

Takeshi Takahashi, Tomoyuki Tagami, Sayuri Yamazaki et al. · The Journal of Experimental Medicine · 2000 · 2.2K citations · Full text

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Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

Jun Shimizu, Sayuri Yamazaki, Takeshi Takahashi et al. · Nature Immunology · 2002 · 1.7K citations

, , +14

1–5 of 3K

Authors

10.3K

  1. HW
    Herman Waldmann

    University of Oxford, United Kingdom

    30 publications · 3.5K citations

    24

    h-index

  2. HN
    Henry N. Claman

    University of Colorado Denver, United States

    26 publications · 1.9K citations

    21

    h-index

  3. HL
    Howard L. Weiner

    Brigham and Women's Hospital, United States

    23 publications · 3.3K citations

    21

    h-index

  4. DW
    David W. Scott

    Duke University, United States

    39 publications · 1K citations

    20

    h-index

  5. SD
    Stephen D. Miller

    Northwestern University, United States

    26 publications · 2.1K citations

    20

    h-index

1–5 of 10.3K

Institutions

1.9K

  1. Harvard University

    Cambridge, United States

    61 h-index

    510 publications

    64.7K citations

  2. Brigham and Women's Hospital

    Boston, United States

    44 h-index

    220 publications

    38.9K citations

  3. National Institutes of Health

    Bethesda, United States

    41 h-index

    243 publications

    20.5K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    40 h-index

    114 publications

    20.6K citations

  5. Yale University

    New Haven, United States

    35 h-index

    172 publications

    18.2K citations

  6. Inserm

    Paris, France

    34 h-index

    222 publications

    18.6K citations

  7. University of Pennsylvania

    Philadelphia, United States

    32 h-index

    173 publications

    12.2K citations

  8. University of Colorado Denver

    Denver, United States

    32 h-index

    149 publications

    15.7K citations

1–8 of 1.9K

Venues

  1. The Journal of Experimental Medicine

    225 publications · 25.2K citations

    89

    h-index

  2. The Journal of Immunology

    JI · 466 publications · 32K citations

    85

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 91 publications · 8.7K citations

    52

    h-index

  4. PubMed

    Repository · 252 publications · 9.7K citations

    48

    h-index

  5. European Journal of Immunology

    EJI · 156 publications · 6.8K citations

    46

    h-index

1–5