Jun Shimizu

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

Takeshi Takahashi, Tomoyuki Tagami, Sayuri Yamazaki et al. · The Journal of Experimental Medicine · 2000 · 2.2K citations · Full text

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

Jun Shimizu, Sayuri Yamazaki, Takeshi Takahashi et al. · Nature Immunology · 2002 · 1.7K citations

Autoimmune Disease, T-regulatory Cell, Immunology +8

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

Takamune Takahashi, Yuhshi Kuniyasu, Masaaki Toda et al. · International Immunology · 1998 · 1.5K citations · Full text

Normal Naive Mice, T-regulatory Cell, Cellular Immunology +19

Foxp3⁺CD25⁺CD4⁺ natural regulatory T cells in dominant self‐tolerance and autoimmune disease

Shimon Sakaguchi, Masahiro Ono, Ruka Setoguchi et al. · Immunological Reviews · 2006 · 1.5K citations · Full text

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

Jun Shimizu, Sayuri Yamazaki, Shimon Sakaguchi · The Journal of Immunology · 1999 · 1.5K citations · Full text

T-regulatory Cell, Immunology, Nk Cells +17