Concepedia

Thymic Tolerance

Thymic Tolerance is a central immune tolerance mechanism by which self-reactive T cells are eliminated during their development in the thymus through negative selection, thereby preventing autoimmunity.

890

Publications

79.6K

Citations

3.6K

Authors

934

Institutions

Publications per year

2017–2026

91

Parents

Publications

890

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

Mark S. Anderson, Emily S. Venanzi, Ludger Klein et al. · Science · 2002 · 2.5K citations

, , +17

T cell tolerance by clonal elimination in the thymus

John W. Kappler, Neal W. Roehm, Philippa Marrack · Cell · 1987 · 2.2K citations

, , +14

Induction by Antigen of Intrathymic Apoptosis of CD4 <sup>+</sup> CD8 <sup>+</sup> TCR <sup>lo</sup> Thymocytes in Vivo

Kenneth M. Murphy, Amy B. Heimberger, Dennis Y. Loh · Science · 1990 · 1.7K citations

, , +17

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

Jun Shimizu, Sayuri Yamazaki, Takeshi Takahashi et al. · Nature Immunology · 2002 · 1.7K citations

, , +14

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

Paweł Kisielow, Horst Blüthmann, Uwe D. Staerz et al. · Nature · 1988 · 1.7K citations

, , +14

1–5 of 890

Authors

3.6K

  1. CB
    Christophe Benoıst

    Harvard University, United States

    17 publications · 4.5K citations

    16

    h-index

  2. DM
    Diane Mathis

    Harvard University, United States

    16 publications · 4.4K citations

    15

    h-index

  3. YT
    Yousuke Takahama

    Tokushima University, Japan

    17 publications · 2.4K citations

    15

    h-index

  4. GA
    Graham Anderson

    University of Birmingham, United Kingdom

    15 publications · 1.1K citations

    14

    h-index

  5. BK
    Bruno Kyewski

    German Cancer Research Center, Germany

    13 publications · 2.4K citations

    13

    h-index

1–5 of 3.6K

Institutions

934

  1. Harvard University

    Cambridge, United States

    39 h-index

    206 publications

    18.4K citations

  2. Inserm

    Paris, France

    26 h-index

    152 publications

    14.7K citations

  3. Walter and Eliza Hall Institute of Medical Research

    Melbourne, Australia

    26 h-index

    101 publications

    11K citations

  4. Brigham and Women's Hospital

    Boston, United States

    25 h-index

    92 publications

    26.8K citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    25 h-index

    84 publications

    12.8K citations

  6. National Institutes of Health

    Bethesda, United States

    23 h-index

    125 publications

    6.8K citations

  7. Tokushima University

    Tokushima, Japan

    23 h-index

    139 publications

    20.8K citations

  8. University of California, San Francisco

    San Francisco, United States

    22 h-index

    112 publications

    11.8K citations

1–8 of 934

Venues

  1. The Journal of Experimental Medicine

    90 publications · 10.5K citations

    56

    h-index

  2. The Journal of Immunology

    JI · 155 publications · 8.9K citations

    54

    h-index

  3. European Journal of Immunology

    EJI · 58 publications · 2.6K citations

    31

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 45 publications · 3.6K citations

    31

    h-index

  5. Nature

    37 publications · 5.7K citations

    29

    h-index

1–5