Concepedia

T Cell Tolerance

T Cell Tolerance is a form of immunological tolerance in which developing or mature T lymphocytes are rendered non-responsive to, or actively suppress immune responses against, specific self or innocuous antigens through central (thymic deletion or diversion to regulatory T cells) and peripheral (anergy, deletion, or regulation) mechanisms, thereby preventing autoimmunity while preserving protective responses to foreign pathogens.

2.8K

Publications

262.8K

Citations

11.8K

Authors

2K

Institutions

Publications per year

2017–2026

287

Variants

T-cell Tolerance

Parents

Children

Publications

2.8K

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor <i>Foxp3 </i>

WanJun Chen, Wenwen Jin, Neil J. Hardegen et al. · The Journal of Experimental Medicine · 2003 · 4.6K citations · Full text

, , +17

‘Actively Acquired Tolerance’ of Foreign Cells

R. E. Billingham, L Brent, P. B. Medawar · Nature · 1953 · 3.1K citations

, , +14

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

Weihong Liu, Amy Putnam, Gregory L. Szot et al. · The Journal of Experimental Medicine · 2006 · 2.6K citations · Full text

, , +17

T cell tolerance by clonal elimination in the thymus

John W. Kappler, Neal W. Roehm, Philippa Marrack · Cell · 1987 · 2.2K citations

, , +14

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

Loise M. Francisco, Victor H. Salinas, Keturah Brown et al. · The Journal of Experimental Medicine · 2009 · 2K citations · Full text

, , +16

1–5 of 2.8K

Authors

11.8K

  1. MS
    Megan Sykes

    Massachusetts General Hospital, United States

    42 publications · 2.5K citations

    29

    h-index

  2. HW
    Herman Waldmann

    University of Oxford, United Kingdom

    32 publications · 4.6K citations

    28

    h-index

  3. MH
    Mohamed H. Sayegh

    Brigham and Women's Hospital, United States

    24 publications · 5K citations

    24

    h-index

  4. JA
    Jeffrey A. Bluestone

    University of California, San Francisco, United States

    25 publications · 6.7K citations

    23

    h-index

  5. DH
    David H. Sachs

    Massachusetts General Hospital, United States

    23 publications · 1.7K citations

    21

    h-index

1–5 of 11.8K

Institutions

2K

  1. Harvard University

    Cambridge, United States

    80 h-index

    899 publications

    128.3K citations

  2. Brigham and Women's Hospital

    Boston, United States

    67 h-index

    392 publications

    77.3K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    52 h-index

    201 publications

    32.5K citations

  4. Inserm

    Paris, France

    50 h-index

    429 publications

    36.2K citations

  5. National Institutes of Health

    Bethesda, United States

    48 h-index

    261 publications

    67.2K citations

  6. Massachusetts General Hospital

    Boston, United States

    43 h-index

    399 publications

    29.1K citations

  7. Yale University

    New Haven, United States

    40 h-index

    161 publications

    20.3K citations

  8. University of Washington

    Seattle, United States

    39 h-index

    187 publications

    24.6K citations

1–8 of 2K

Venues

  1. The Journal of Immunology

    JI · 579 publications · 43.1K citations

    106

    h-index

  2. The Journal of Experimental Medicine

    203 publications · 40.9K citations

    99

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 108 publications · 10.3K citations

    58

    h-index

  4. European Journal of Immunology

    EJI · 178 publications · 9.7K citations

    56

    h-index

  5. Immunity

    54 publications · 13.2K citations

    49

    h-index

1–5