Concepedia

Application of Process Analytical Technology for Monitoring Freeze-Drying of an Amorphous Protein Formulation: Use of Complementary Tools for Real-Time Product Temperature Measurements and Endpoint Detection

Stefan Schneid, Robert E. Johnson, M. Laviniam Lewis, Peter Stärtzel, Henning Gieseler

Journal of Pharmaceutical Sciences · 2015 · 13 citations · 12 references

DOI

Concepts

References

12

Freeze-Drying Process Design by Manometric Temperature Measurement: Design of a Smart Freeze-Dryer

Xiaolin Tang, Steven L. Nail, Michael J. Pikal · Pharmaceutical Research · 2005 · 168 citations

, , +15

Systematic investigation of the effect of lyophilizate collapse on pharmaceutically relevant proteins I: Stability after freeze‐drying

K. Schersch, O. Betz, Patrick Garidel et al. · Journal of Pharmaceutical Sciences · 2009 · 123 citations

, , +16

Lyophilization of protein formulations in vials: Investigation of the relationship between resistance to vapor flow during primary drying and small‐scale product collapse

David E. Overcashier, Thomas W. Patapoff, Chung C. Hsu · Journal of Pharmaceutical Sciences · 1999 · 112 citations

, , +16

Freeze-Dry Microscopy of Protein/Sugar Mixtures: Drying Behavior, Interpretation of Collapse Temperatures and a Comparison to Corresponding Glass Transition Data

Eva Meister, Henning Gieseler · Journal of Pharmaceutical Sciences · 2008 · 105 citations · Full text

, , +16

Rapid determination of dry layer mass transfer resistance for various pharmaceutical formulations during primary drying using product temperature profiles

Wei Y. Kuu, Lisa M. Hardwick, Michael J. Akers · International Journal of Pharmaceutics · 2006 · 77 citations

, , +14