Concepedia

Inactivating PSMB5 Mutations and P-Glycoprotein (Multidrug Resistance-Associated Protein/ATP-Binding Cassette B1) Mediate Resistance to Proteasome Inhibitors: Ex Vivo Efficacy of (Immuno)Proteasome Inhibitors in Mononuclear Blood Cells from Patients with Rheumatoid Arthritis

Sue Ellen Verbrugge, Yehuda G. Assaraf, Ben A. C. Dijkmans, George L. Scheffer, Marjon Al, Debby den Uyl, Ruud Oerlemans, Elena T. Chan, Christopher J. Kirk, Godefridus J. Peters,

Journal of Pharmacology and Experimental Therapeutics · 2012 · 107 citations · 33 references

DOI

Concepts

References

33

Antitumor Activity of PR-171, a Novel Irreversible Inhibitor of the Proteasome

Susan D. Demo, Christopher J. Kirk, Monette Aujay et al. · Cancer Research · 2007 · 675 citations · Full text

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A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

Tony Muchamuel, Michael Basler, Monette Aujay et al. · Nature Medicine · 2009 · 595 citations

, , +17

Proteasome Inhibitors in Cancer Therapy: Lessons from the First Decade

Robert Z. Orlowski, Deborah J. Kuhn · Clinical Cancer Research · 2008 · 582 citations

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The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis

Kirsten Neubert, Silke Meister, Katrin Moser et al. · Nature Medicine · 2008 · 576 citations

, , +16

Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress

Ulrike Seifert, Frédéric Ebstein, Dawadschargal Bech‐Otschir et al. · Cell · 2010 · 542 citations · Full text

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