Deborah J. Kuhn

Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma

Deborah J. Kuhn, Qing Chen, Peter M. Voorhees et al. · Blood · 2007 · 768 citations · Full text

Medicine, Oncology, Pharmacology +13

Proteasome Inhibitors in Cancer Therapy: Lessons from the First Decade

Robert Z. Orlowski, Deborah J. Kuhn · Clinical Cancer Research · 2008 · 582 citations

Medicine, Oncology, Pharmacology +14

<i>In Vitro</i> and <i>In Vivo</i> Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells

Dharminder Chauhan, Ze Tian, Bin Zhou et al. · Clinical Cancer Research · 2011 · 326 citations · Full text

Medicine, Medicinal Chemistry, Oncology +13

Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells

Di Chen, Kenyon G. Daniel, Marina S. Chen et al. · Biochemical Pharmacology · 2005 · 306 citations

Medicine, Oncology, Pharmacology +17

Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy

Qing Chen, Weilin Xie, Deborah J. Kuhn et al. · Blood · 2008 · 267 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +8