Concepedia

Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia

Fang Cao, Elizabeth C. Townsend, Hacer Karataş, Jing Xu, Li Li, Shirley Lee, Liu Liu, Yong Chen, Peter Ouillette, Jidong Zhu,

Molecular Cell · 2014 · 302 citations · 43 references

DOIFull text

Open access

Concepts

References

43

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake Delmore, Ghayas C. Issa, Madeleine E. Lemieux et al. · Cell · 2011 · 2.8K citations · Full text

, , +10

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Johannes Zuber, Junwei Shi, Eric Wang et al. · Nature · 2011 · 1.9K citations

, , +9

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Mark A. Dawson, Rab K. Prinjha, Antje Dittmann et al. · Nature · 2011 · 1.5K citations · Full text

, , +10

MLL Targets SET Domain Methyltransferase Activity to Hox Gene Promoters

Thomas A. Milne, Scott Briggs, Hugh W. Brock et al. · Molecular Cell · 2002 · 1.1K citations · Full text

, , +12

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen et al. · Cancer Cell · 2011 · 934 citations · Full text

, , +10