Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia

Fang Cao, Elizabeth C. Townsend, Hacer Karataş, +14

Molecular Cell

Hematological MalignancyChromatinMixed-phenotype Acute LeukemiaMixed-lineage LeukemiaAdult T-cell Leukemia-lymphoma +4

High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein–Protein Interaction

Hacer Karataş, Elizabeth C. Townsend, Fang Cao, +6

Journal of the American Chemical Society

Mll1/wdr5 Protein–protein InteractionDrug TargetMixed LineageMixed-phenotype Acute LeukemiaMolecular Biology +16

Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)–Mixed Lineage Leukemia (MLL) Protein–Protein Interaction

Hacer Karataş, Yangbing Li, Liu Liu, +17

Journal of Medicinal Chemistry

Structure-Based Design of High-Affinity Macrocyclic Peptidomimetics to Block the Menin-Mixed Lineage Leukemia 1 (MLL1) Protein–Protein Interaction

Haibin Zhou, Liu Liu, Jing Huang, +5

Journal of Medicinal Chemistry

The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis

Luca Laraia, Alexandra Friese, Dale Corkery, +17

Nature Chemical Biology

Cell AutophagyAutophagyLipophagyCellular BiochemistryAutophagosome Biogenesis +3

TEAD–YAP Interaction Inhibitors and MDM2 Binders from DNA‐Encoded Indole‐Focused Ugi Peptidomimetics

Verena B. K. Kunig, Marco Potowski, Mohammad Akbarzadeh, +18

Angewandte Chemie International Edition

Tead–yap Interaction InhibitorsUgi PeptidomimeticsMolecular BiologyChemical BiologyHot Spot +18

Analysis of the Binding of Mixed Lineage Leukemia 1 (MLL1) and Histone 3 Peptides to WD Repeat Domain 5 (WDR5) for the Design of Inhibitors of the MLL1−WDR5 Interaction

Hacer Karataş, Elizabeth C. Townsend, Denzil Bernard, +2

Journal of Medicinal Chemistry

Mll1 ActivityProtein AssemblyMll1−wdr5 InteractionMixed-phenotype Acute LeukemiaMolecular Biology +15

MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency

Hui Zhang, Srimonta Gayen, Jie Xiong, +10

Cell stem cell

Induced Pluripotent Stem CellDevelopmental BiologyMedicineStem Cell ResearchNaive Pluripotency +3

Discovery of Covalent Inhibitors Targeting the Transcriptional Enhanced Associate Domain Central Pocket

Hacer Karataş, Mohammad Akbarzadeh, Hélène Adihou, +15

Journal of Medicinal Chemistry

A protein tertiary structure mimetic modulator of the Hippo signalling pathway

Hélène Adihou, R. Gopalakrishnan, Tim Förster, +19

Nature Communications