Concepedia

Dna Methyltransferases

DNA Methyltransferase is an enzyme that catalyzes the transfer of a methyl group to cytosine residues in DNA, thereby mediating DNA methylation and contributing to epigenetic regulation of gene expression, particularly in the context of transcriptional silencing in cancer.

5.1K

Publications

403.1K

Citations

23.6K

Authors

3.7K

Institutions

Publications per year

2017–2026

1.2K

Variants

Dna Methyltransferase

Parents

Publications

5.1K

<i>MGMT</i> Gene Silencing and Benefit from Temozolomide in Glioblastoma

Monika E. Hegi, Annie‐Claire Diserens, Thierry Gorlia et al. · New England Journal of Medicine · 2005 · 7.3K citations · Full text

, , +17

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Masaki Okano, Daphne W. Bell, Daniel A. Haber et al. · Cell · 1999 · 6.1K citations · Full text

, , +15

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

En Li, Timothy H. Bestor, Rudolf Jaenisch · Cell · 1992 · 4K citations

, , +14

Inactivation of the DNA-Repair Gene<i>MGMT</i>and the Clinical Response of Gliomas to Alkylating Agents

Manel Esteller, Jesús García‐Foncillas, Esther Andion et al. · New England Journal of Medicine · 2000 · 2.2K citations · Full text

, , +17

Cellular differentiation, cytidine analogs and DNA methylation

Peter A. Jones, Shirley M. Taylor · Cell · 1980 · 1.9K citations

, , +16

1–5 of 5.1K

Authors

23.6K

  1. AJ
    Albert Jeltsch

    University of Stuttgart, Germany

    89 publications · 8K citations

    52

    h-index

  2. RJ
    Richard J. Roberts

    New England Biolabs (United States), United States

    37 publications · 8K citations

    32

    h-index

  3. SC
    Steven Clarke

    University of California, Los Angeles, United States

    39 publications · 3.5K citations

    31

    h-index

  4. XC
    Xiaodong Cheng

    Emory University, United States

    34 publications · 5.3K citations

    30

    h-index

  5. MS
    Moshe Szyf

    McGill University, Canada

    31 publications · 2.9K citations

    29

    h-index

1–5 of 23.6K

Institutions

3.7K

  1. Harvard University

    Cambridge, United States

    62 h-index

    346 publications

    92.6K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    54 h-index

    617 publications

    46K citations

  3. University of California, Los Angeles

    Los Angeles, United States

    52 h-index

    320 publications

    51.2K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    51 h-index

    153 publications

    26.2K citations

  5. Johns Hopkins University

    Baltimore, United States

    51 h-index

    303 publications

    42.4K citations

  6. Chinese Academy of Sciences

    Beijing, China

    49 h-index

    487 publications

    47K citations

  7. New England Biolabs (United States)

    Ipswich, United States

    48 h-index

    280 publications

    37.3K citations

  8. The University of Texas MD Anderson Cancer Center

    Houston, United States

    46 h-index

    261 publications

    30.7K citations

1–8 of 3.7K

Venues

  1. Journal of Biological Chemistry

    JBC · 273 publications · 26K citations

    90

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 126 publications · 19.8K citations

    80

    h-index

  3. Nucleic Acids Research

    291 publications · 25.3K citations

    76

    h-index

  4. PubMed

    Repository · 168 publications · 14.5K citations

    57

    h-index

  5. Journal of Molecular Biology

    JMB · 117 publications · 9.6K citations

    55

    h-index

1–5