Concepedia

Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties

Hans Richter, G. Martin Benson, Konrad Bleicher, Denise Blum, Evelyne Chaput, Nicole Clemann, Song Feng, Christophe Gardès, Uwe Grether, Peter Hartman,

Bioorganic & Medicinal Chemistry Letters · 2011 · 78 citations · 31 references

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References

31

Identification of a Nuclear Receptor for Bile Acids

Makoto Makishima, Arthur Y. Okamoto, Joyce J. Repa et al. · Science · 1999 · 2.7K citations

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Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

Derek J. Parks, Steven G. Blanchard, Randy K. Bledsoe et al. · Science · 1999 · 2.2K citations

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Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

Haibo Wang, Jasmine Chen, Kevin Hollister et al. · Molecular Cell · 1999 · 1.6K citations · Full text

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Identification of a nuclear receptor that is activated by farnesol metabolites

Barry M. Forman, Elizabeth C. Goode, Jasmine Chen et al. · Cell · 1995 · 1.2K citations · Full text

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Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

Yanqiao Zhang, Florence Ying Lee, Gabriel Barrera et al. · Proceedings of the National Academy of Sciences · 2006 · 937 citations · Full text

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