Fenofibrate and Rosiglitazone Lower Serum Triglycerides with Opposing Effects on Body Weight

Evelyne Chaput, Régis Saladin, Martine Silvestre, +1

Biochemical and Biophysical Research Communications

ObesityNutritionMetabolic SyndromeLipid DisorderOpposing Effects +10

Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport

Eric J. Niesor, Christine Magg, Naoto Ogawa, +14

Journal of Lipid Research

Lipid PeroxidationDalcetrapib ≤3 µMCellular PharmacologyLipid MovementMolecular Pharmacology +14

Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties

Hans Richter, G. Martin Benson, Konrad Bleicher, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesAdme Properties +7

Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes

Hans Richter, G. Martin Benson, Denise Blum, +12

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyActive Fxr AgonistsMedicineDiabetesPharmacological Agent +6

Differential regulation of bile acid and cholesterol metabolism by the farnesoid X receptor in Ldlr −/− mice versus hamsters

Christophe Gardès, Evelyne Chaput, Andreas Staempfli, +3

Journal of Lipid Research

Effect of Compounds Affecting ABCA1 Expression and CETP Activity on the HDL Pathway Involved in Intestinal Absorption of Lutein and Zeaxanthin

Eric J. Niesor, Evelyne Chaput, Jean‐Luc Mary, +5

Lipids

Cetp ActivityHealth SciencesBiochemistryMedicineLiver Physiology +12

6-Alkoxy-5-aryl-3-pyridinecarboxamides, a New Series of Bioavailable Cannabinoid Receptor Type 1 (CB1) Antagonists Including Peripherally Selective Compounds

Stephan Röver, Mirjana Andjelković, Agnès Bénardeau, +10

Journal of Medicinal Chemistry

PharmacotherapyNew SeriesCannabinoid PharmacologySocial SciencesMedicinal Chemistry +15

Fenofibrate induces a selective increase of protein-bound homocysteine in rodents: a PPARα-mediated effect

Christiane Legendre, E Caussé, Evelyne Chaput, +3

Biochemical and Biophysical Research Communications

Molecular PharmacologyProtein-bound HomocysteineBiochemistryFunctional SelectivityMedicine +7

Effect of dalcetrapib, a CETP modulator, on non-cholesterol sterol markers of cholesterol homeostasis in healthy subjects

Eric J. Niesor, Evelyne Chaput, Andreas Staempfli, +3

Atherosclerosis

OxysterolCardiovascular DiseaseMedicinePhysiologyNon-cholesterol Sterol Markers +7

Fenofibrate protects lipoproteins from lipid peroxidation: Synergistic interaction with α‐tocopherol

Evelyne Chaput, Dominique Maubrou‐Sanchez, François Bellamy, +1

Lipids