Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity

Marjolein Soethoudt, Uwe Grether, Jürgen Fingerle, +29

Nature Communications

Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes

Agnès Bénardeau, Jörg Benz, Alfred Binggeli, +12

Bioorganic & Medicinal Chemistry Letters

Diabetes ManagementMedicineDiabetesPharmacological AgentPharmacotherapy +5

An Oxidation-Labile Traceless Linker for Solid-Phase Synthesis

Frank Stieber, Uwe Grether, Herbert Waldmann

Angewandte Chemie International Edition

Materials ScienceCombinatorial ChemistryChemical EngineeringExperimental SynthesisEngineering +11

Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

Elliot D. Mock, Mohammed Ahmed Mustafa, Ozge Gunduz‐Cinar, +35

Nature Chemical Biology

Knockout MouseEmotional BehaviorBehavioral NeuroscienceMedicineBehavioral Pharmacology +10

Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB₂ Receptor Expression and Ligand Engagement in Human Cells

Marjolein Soethoudt, Sara Christina Stolze, Matthias V. Westphal, +15

Journal of the American Chemical Society

Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties

Hans Richter, G. Martin Benson, Konrad Bleicher, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesAdme Properties +7

Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning

David F. Nippa, Kenneth Atz, Remo Hohler, +13

Nature Chemistry

Structure-based design of indole propionic acids as novel PPARα/γ co-agonists

Bernd Kuhn, Hans Hilpert, Jörg Benz, +6

Bioorganic & Medicinal Chemistry Letters

BiochemistryFunctional SelectivityMedicineNatural SciencesReceptor (Biochemistry) +5

Discovery of a High Affinity and Selective Pyridine Analog as a Potential Positron Emission Tomography Imaging Agent for Cannabinoid Type 2 Receptor

Roger Slavik, Uwe Grether, Adrienne Müller Herde, +7

Journal of Medicinal Chemistry

Imaging AgentPharmacotherapyExperimental PharmacologyCannabinoid PharmacologyPharmaceutical Chemistry +21

Prospective de novo drug design with deep interactome learning

Kenneth Atz, Leandro Cotos, Clemens Isert, +14

Nature Communications