Renin inhibition by substituted piperidines: A novel paradigm for the inhibition of monomeric aspartic proteinases?

Christian Oefner, Alfred Binggeli, Volker Breu, +16

Chemistry & Biology

Inhibitory ActivityMedicinal ChemistryBioorganic ChemistryBiochemistryNatural Sciences +10

Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes

Agnès Bénardeau, Jörg Benz, Alfred Binggeli, +12

Bioorganic & Medicinal Chemistry Letters

Diabetes ManagementMedicineDiabetesPharmacological AgentPharmacotherapy +5

Substituted piperidines - highly potent renin inhibitors due to induced fit adaptation of the active site

Eric Vieira, Alfred Binggeli, Volker Breu, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryFunctional SelectivityNatural SciencesMedicine +11

The Response of Trained Athletes to Six Weeks of Endurance Training in Hypoxia or Normoxia

Nuno Ventura, Hans Hoppeler, R. Seiler, +3

International Journal of Sports Medicine

Trained AthletesPhysical ActivityHigh-intensity Interval TrainingEndurance Trained CyclistsEndurance Training +16

Structure-based design of indole propionic acids as novel PPARα/γ co-agonists

Bernd Kuhn, Hans Hilpert, Jörg Benz, +6

Bioorganic & Medicinal Chemistry Letters

BiochemistryFunctional SelectivityMedicineNatural SciencesReceptor (Biochemistry) +5

Piperidine-renin inhibitors compounds with improved physicochemical properties

Rolf Güller, Alfred Binggeli, Volker Breu, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceMedicineRational Drug DesignPiperidine-renin Inhibitors +4

Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists

Uwe Grether, Agnès Bénardeau, Jörg Benz, +11

ChemMedChem

Molecular PharmacologyMedicinal ChemistryPharmaceutical ScienceX-ray-guided Design ApproachPharmacological Study +12

Novel, non-peptidic somatostatin receptor subtype 5 antagonists improve glucose tolerance in rodents

Urs Sprecher, Peter J. Mohr, Rainer E. Martin, +5

Regulatory Peptides

Molecular PharmacologyMetabolic SyndromeGlucose ToleranceFunctional SelectivityMedicine +8

Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists

Rainer E. Martin, Peter J. Mohr, Hans Peter Maerki, +9

Bioorganic & Medicinal Chemistry Letters

Benzoxazole PiperidinesFunctional SelectivityPharmacologyMechanism Of ActionPharmacological Agent +4

Piperidinyl-nicotinamides as potent and selective somatostatin receptor subtype 5 antagonists

André Alker, Alfred Binggeli, Andreas D. Christ, +4

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyFunctional SelectivityNicotinePharmacologyMechanism Of Action +4