Phenylethynyl-pyrrolo[1,2-a]pyrazine: A new potent and selective tool in the mGluR5 antagonists arena

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

F. Gasparini, Kurt Lingenhöhl, Natacha Stoehr et al. · Neuropharmacology · 1999 · 720 citations

Medicine, Medicinal Chemistry, Pharmacology +7

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine:  A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

Nicholas D. P. Cosford, Lida Tehrani, Jeffrey Roppe et al. · Journal of Medicinal Chemistry · 2002 · 400 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia

Katherine Walker, A Reeve, M. Bowes et al. · Neuropharmacology · 2001 · 228 citations

Life Sciences, Neurobiology, Neuroscience +17

Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking

Michela Tessari, Maria Pilla, Michela Andreoli et al. · European Journal of Pharmacology · 2004 · 166 citations

Medicine, Neuroscience, Pharmacology +16

[3H]-Methoxymethyl-MTEP and [3H]-Methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

Nicholas D. P. Cosford, Jeffrey Roppe, Lida Tehrani et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 146 citations · Full text

Medicine, Neuroscience, Pharmacology +11