Concepedia

PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR

Rosa Bernardi, Ilhem Guernah, David Jin, Silvia Grisendi, Andrea Alimonti, Julie Teruya‐Feldstein, Carlos Cordon‐Cardo, M. Celeste Simon, Shahin Rafii, Pier Paolo Pandolfi

Nature · 2006 · 377 citations · 30 references

DOI

Concepts

References

30

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Dos D. Sarbassov, Siraj M. Ali, Do‐Hyung Kim et al. · Current Biology · 2004 · 2.7K citations · Full text

, , +12

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

David Lyden, Koichi Hattori, Sérgio Dias et al. · Nature Medicine · 2001 · 1.9K citations

, , +16

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

Akira Kakizuka, Wilson H. Miller, Kazuhiko Umesono et al. · Cell · 1991 · 1.5K citations · Full text

, , +11

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

James Brugarolas, Kui Lei, Rebecca L. Hurley et al. · Genes & Development · 2004 · 1.4K citations · Full text

, , +17

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

Hugues de Thé, Catherine Lavau, Agnès Marchio et al. · Cell · 1991 · 1.4K citations

, , +10