James Brugarolas

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

James Brugarolas, Kui Lei, Rebecca L. Hurley et al. · Genes & Development · 2004 · 1.4K citations · Full text

Medicine, Cell Biology, Oncology +17

Radiation-induced cell cycle arrest compromised by p21 deficiency

James Brugarolas, Chitra Chandrasekaran, Jeffrey I. Gordon et al. · Nature · 1995 · 1.2K citations

Life Sciences, Cell Biology, Molecular Biology +14

BAP1 loss defines a new class of renal cell carcinoma

Samuel Peña‐Llopis, Silvia Vega-Rubín-de-Celis, Arnold Liao et al. · Nature Genetics · 2012 · 995 citations · Full text

Medicine, Cancer Biology, Oncology +13

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

Pradip K. Majumder, Phillip G. Febbo, Rachel Bikoff et al. · Nature Medicine · 2004 · 956 citations

Medicine, Oncology, Urology +15

Targeting renal cell carcinoma with a HIF-2 antagonist

Wenfang Chen, Haley Hill, Alana Christie et al. · Nature · 2016 · 723 citations

Medicine, Cancer Biology, Oncology +10